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| Descriptor English: | Tissue Plasminogen Activator | ||||||
| Descriptor Spanish: |
Activador de Tejido Plasminógeno
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| Descriptor Portuguese: | Ativador de Plasminogênio Tecidual | ||||||
| Descriptor French: | Activateur tissulaire du plasminogène | ||||||
| Entry term(s): |
Actilyse Activase Alteplase Lysatec rt PA Lysatec rt-PA Lysatec rtPA Plasminogen Activator, Tissue Plasminogen Activator, Tissue Type Plasminogen Activator, Tissue-Type T Plasminogen Activator T-Plasminogen Activator TTPA Tisokinase Tissue Activator D 44 Tissue Activator D-44 Tissue Type Plasminogen Activator Tissue-Type Plasminogen Activator |
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| Tree number(s): |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D010959 | ||||||
| Scope note: | A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
Fibrinolytic Agents |
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| Registry Number: | EC 3.4.21.68 | ||||||
| Previous Indexing: |
Enzyme Activation (1974-1975) Peptide Hydrolases (1975) Plasminogen Activators (1976-1985) |
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| Public MeSH Note: | 98; see ALTEPLASE 1992-97; see PLASMINOGEN ACTIVATOR, TISSUE-TYPE 1986-91 |
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| History Note: | 98(86) |
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| DeCS ID: | 30438 | ||||||
| Unique ID: | D010959 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1986/01/01 | ||||||
| Date of Entry: | 1985/06/12 | ||||||
| Revision Date: | 2016/07/01 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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Tissue Plasminogen Activator
- Preferred
Activase
- Narrower
Actilyse
- Narrower
| Concept UI |
M0016991 |
| Scope note | A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases. |
| Preferred term | Tissue Plasminogen Activator |
| Entry term(s) |
Alteplase Plasminogen Activator, Tissue Plasminogen Activator, Tissue Type Plasminogen Activator, Tissue-Type T Plasminogen Activator T-Plasminogen Activator TTPA Tisokinase Tissue Activator D 44 Tissue Activator D-44 Tissue Type Plasminogen Activator Tissue-Type Plasminogen Activator |
| Concept UI |
M0333862 |
| Preferred term | Activase |
| Concept UI |
M0016992 |
| Preferred term | Actilyse |
| Entry term(s) |
Lysatec rt PA Lysatec rt-PA Lysatec rtPA |
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