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Descriptor English: Tissue Plasminogen Activator
Descriptor Spanish: Activador de Tejido Plasminógeno
Descriptor activador tisular del plasminógeno
Entry term(s) activador del plasminógeno de tipo tisular
activador del plasminógeno tisular
activador del plasminógeno-T
alteplasa
tPA
Scope note: Enzima proteolítica de la familia serina proteasa, que se encuentra en muchos tejidos, y que convierte al PLASMINÓGENO en PLASMINA. Tiene actividad de unión a la fibrina y es inmunológicamente diferente del ACTIVADOR DEL PLAMINÓGENO DE TIPO UROQUINASA. La secuencia primaria, compuesta de 527 aminoácidos, es idéntica tanto en las proteasas naturales como en las sintéticas.
Descriptor Portuguese: Ativador de Plasminogênio Tecidual
Descriptor French: Activateur tissulaire du plasminogène
Entry term(s): Actilyse
Activase
Altéplase
t-PA (t-Plasminogen Activator)
tPA (tissue Plasminogen Activator)
Tree number(s): D08.811.277.656.300.760.875
D08.811.277.656.959.350.875
D12.776.124.125.662.768
D23.119.970
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010959
Scope note: A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Pharm Action: Fibrinolytic Agents
Registry Number: EC 3.4.21.68
DeCS ID: 30438
Unique ID: D010959
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1985/06/12
Revision Date: 2016/07/01
Activateur tissulaire du plasminogène - Preferred
Concept UI M0016991
Preferred term Activateur tissulaire du plasminogène
Entry term(s) Altéplase
t-PA (t-Plasminogen Activator)
tPA (tissue Plasminogen Activator)
Activase - Narrower
Concept UI M0333862
Preferred term Activase
Actilyse - Narrower
Concept UI M0016992
Preferred term Actilyse



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