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Descriptor English: Paclitaxel
Descriptor Spanish: Paclitaxel
Descriptor paclitaxel
Scope note: Ciclodecano aislado de la corteza del árbol tejo del Pacífico, TAXUS BREVIFOLIA. Estabiliza los MICROTÚBULOS en su forma polimerizada, lo que lleva la muerte celular.
Descriptor Portuguese: Paclitaxel
Descriptor French: Paclitaxel
Entry term(s): 7 epi Taxol
7-epi-Taxol
Anzatax
Bris Taxol
NSC 125973
NSC-125973
NSC125973
Onxol
Paclitaxel, (4 alpha)-Isomer
Paxene
Praxel
Taxol
Taxol A
Taxol, Bris
Tree number(s): D02.455.426.392.368.242.888.777
D02.455.849.291.850.777
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017239
Scope note: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents, Phytogenic
Tubulin Modulators
Registry Number: P88XT4IS4D
CAS Type 1 Name: Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,1-2alpha,12aalpha,12balpha))-
Previous Indexing: Alkaloids (1982-1992)
Terpenes (1977-1981)
Public MeSH Note: 95; was TAXOL 1993-94; TAXOL A was indexed under ALKALOIDS 1982-92 & TERPENES 1977-81
Online Note: use PACLITAXEL to search TAXOL 1993-94; use PACLITAXEL (NM) to search TAXOL A 1977-92
History Note: 95; was TAXOL 1993-94; was TAXOL A (NM) 1977-92
DeCS ID: 30485
Unique ID: D017239
NLM Classification: QV 269
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1993/01/01
Date of Entry: 1999/11/04
Revision Date: 2014/10/14
Paclitaxel - Preferred
Concept UI M0026156
Scope note A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Preferred term Paclitaxel
Anzatax - Narrower
Concept UI M0474878
Preferred term Anzatax
NSC-125973 - Narrower
Concept UI M0352957
Preferred term NSC-125973
Entry term(s) NSC 125973
NSC125973
Taxol - Narrower
Concept UI M0026157
Preferred term Taxol
Entry term(s) Bris Taxol
Taxol A
Taxol, Bris
Paclitaxel, (4 alpha)-Isomer - Narrower
Concept UI M0329331
Preferred term Paclitaxel, (4 alpha)-Isomer
Paxene - Narrower
Concept UI M0352959
Preferred term Paxene
Praxel - Narrower
Concept UI M0474881
Preferred term Praxel
7-epi-Taxol - Related but not broader or narrower
Concept UI M0026155
Preferred term 7-epi-Taxol
Entry term(s) 7 epi Taxol
Onxol - Narrower
Concept UI M0474880
Preferred term Onxol



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