DeCS

Descriptor English:

Clozapine

Descriptor Spanish:

Clozapina

Spanish from Spain

Descriptor

clozapina

Scope note:

Dibenzodiacepina tricíclica, clasificada como agente antipsicótico atípico. Se une a diversos tipos de receptores del sistema nervioso central y muestra un único perfil farmacológico. La clozapina es un antagonista de la serotonina, a la que se une fuertemente en los subtipos de receptores 5-HT 2A-2C. También muestra una marcada afinidad por algunos receptores dopaminérgicos, si bien muestra un débil antagonismo con el receptor D2 de dopamina, un receptor que se cree que modula la actividad neuroléptica. El principal efecto adverso asociado con la administracion de este agente es la agranulocitosis.

Descriptor Portuguese:

Clozapina

Descriptor French:

Clozapine

Tree number(s):

D03.633.300.240.220

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D003024

Scope note:

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Serotonin Antagonists
Antipsychotic Agents
GABA Antagonists

Registry Number:

J60AR2IKIC

CAS Type 1 Name:

5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-

DeCS ID:

3051

Unique ID:

D003024

Documents indexed in the Virtual Health Library (VHL):

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