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Descriptor English: Receptors, N-Methyl-D-Aspartate
Descriptor Spanish: Receptores de N-Metil-D-Aspartato
Descriptor receptores de N-metil-D-aspartato
Entry term(s) complejo del ionóforo receptor de NMDA
receptor de N-metil-D-aspartato
receptor de NMDA
receptores NMDA
Scope note: Clase de receptores ionotrópicos del glutamato que se caracterizan por su afinidad por el N-metil-D-aspartato. Los receptores NMDA tienen un sitio de unión alostérico para la glicina que debe estar ocupado para que el canal se abra de manera eficiente y un sitio dentro del propio canal al cual se unen los iones magnesio en una forma que depende del voltaje. La dependencia positiva del voltaje de la conductancia del canal y la elevada permeabilidad del canal conductor a los iones calcio (así como a los cationes monovalentes) son importantes en la excitotoxicidad y en la plasticidad neuronal.
Descriptor Portuguese: Receptores de N-Metil-D-Aspartato
Descriptor French: Récepteurs du N-méthyl-D-aspartate
Entry term(s): N Methyl D Aspartate Receptor
N Methyl D Aspartate Receptors
N Methylaspartate Receptors
N-Methyl-D-Aspartate Receptor
N-Methyl-D-Aspartate Receptors
N-Methylaspartate Receptors
NMDA Receptor
NMDA Receptor Ionophore Complex
NMDA Receptor-Ionophore Complex
NMDA Receptors
Receptor, N-Methyl-D-Aspartate
Receptor, NMDA
Receptors, N Methyl D Aspartate
Receptors, N Methylaspartate
Receptors, N-Methylaspartate
Receptors, NMDA
Tree number(s): D12.776.157.530.400.400.500.500
D12.776.543.550.450.500.200.500
D12.776.543.585.400.500.200.500
D12.776.543.750.720.200.450.400.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016194
Scope note: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Receptors, Cell Surface (1973-1984)
Receptors, Neurotransmitter (1985-1990)
Public MeSH Note: 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92
Online Note: use RECEPTORS, N-METHYL-D-ASPARTATE to search RECEPTOR, N-METHYL-D-ASPARTATE & N-METHYL-D-ASPARTATE RECEPTOR 1991-92
History Note: 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92
Entry Version: RECEPT NMDA
DeCS ID: 30889
Unique ID: D016194
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/05/31
Revision Date: 2020/05/27
Receptors, N-Methyl-D-Aspartate - Preferred
Concept UI M0024713
Scope note A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
Preferred term Receptors, N-Methyl-D-Aspartate
Entry term(s) N Methyl D Aspartate Receptor
N Methyl D Aspartate Receptors
N Methylaspartate Receptors
N-Methyl-D-Aspartate Receptor
N-Methyl-D-Aspartate Receptors
N-Methylaspartate Receptors
NMDA Receptor
NMDA Receptor Ionophore Complex
NMDA Receptor-Ionophore Complex
NMDA Receptors
Receptor, N-Methyl-D-Aspartate
Receptor, NMDA
Receptors, N Methyl D Aspartate
Receptors, N Methylaspartate
Receptors, N-Methylaspartate
Receptors, NMDA



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