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Descriptor English: Superantigens
Descriptor Spanish: Superantígenos
Descriptor superantígenos
Entry term(s) superantígeno
Scope note: Antígenos microbianos que tienen en común un efecto activador muy potente en los linfocitos T que tienen una región variable específica. Los superantígenos establecen un enlace cruzado de la región variable con las proteínas del complejo principal de histocompatibilidad (MHC) de clase II independientemente de la unión del péptido en el bolsillo del receptor del linfocito T. El resultado es una expansión transitoria y la posterior muerte y anergia de los linfocitos T con las regiones variables apropiadas.
Descriptor Portuguese: Superantígenos
Descriptor French: Superantigènes
Entry term(s): Superantigen
Tree number(s): D23.050.820
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018089
Scope note: Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
Annotation: coordinate IM with specific microbe /immunol (IM); for interaction of superantigens with endotoxins, coordinate with ENDOTOXINS or specifics
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: specific antigens (1989-1993)
Public MeSH Note: 94
History Note: 94
Related: Apoptosis MeSH
Clonal Anergy MeSH
Receptors, Antigen, T-Cell, alpha-beta MeSH
DeCS ID: 31023
Unique ID: D018089
NLM Classification: QW 573
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1994/01/01
Date of Entry: 1993/07/01
Revision Date: 2020/05/27
Superantigens - Preferred
Concept UI M0027285
Scope note Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
Preferred term Superantigens
Entry term(s) Superantigen



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