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Descriptor English: Mice, Inbred mdx
Descriptor Spanish: Ratones Endogámicos mdx
Descriptor ratones endogámicos mdx
Entry term(s) ratones consanguíneos mdx
Scope note: Cepa de ratones que surgen por mutación espontánea (mdx) en ratones endogámicos C57BL. Esta mutación está ligada al cromosoma X y produce animales homocigóticos viables que no poseen distrofina, una proteína muscular, tienen altos niveles de enzimas musculares en el suero, y poseen lesiones histológicas similares a la distrofia muscular humana. Las características histológicas, nexos y posición del mapa de mdx hace que estos ratones sean un modelo animal inestimable en el estudio de la distrofia muscular de Duchenne.
Descriptor Portuguese: Camundongos Endogâmicos mdx
Descriptor French: Souris de lignée mdx
Entry term(s): Inbred mdx Mice
Inbred mdx Mouse
Mice, mdx
Mouse, Inbred mdx
Mouse, mdx
mdx Mice
mdx Mouse
Tree number(s): B01.050.050.199.520.520.420.500
B01.050.150.900.649.313.992.635.505.500.400.420.500
B01.050.150.900.649.313.992.635.505.500.550.265
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018101
Scope note: A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.
Annotation: NIM with no qualifiers when experimental animal; check the tag MICE
Allowable Qualifiers: AB abnormalities
AH anatomy & histology
BL blood
CF cerebrospinal fluid
CL classification
EM embryology
GD growth & development
GE genetics
IM immunology
IN injuries
ME metabolism
MI microbiology
PH physiology
PS parasitology
PX psychology
SU surgery
UR urine
VI virology
Previous Indexing: Mice, Inbred C57BL (1984-1993)
Mice, Mutant Strains (1984-1993)
Public MeSH Note: 94
History Note: 94
Related: Muscular Dystrophies MeSH
DeCS ID: 31309
Unique ID: D018101
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1994/01/01
Date of Entry: 1993/06/03
Revision Date: 2017/07/11
Mice, Inbred mdx - Preferred
Concept UI M0027297
Scope note A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.
Preferred term Mice, Inbred mdx
Entry term(s) Inbred mdx Mice
Inbred mdx Mouse
Mice, mdx
Mouse, Inbred mdx
Mouse, mdx
mdx Mice
mdx Mouse



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