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Descriptor English: Mice, Inbred mdx
Descriptor Spanish: Ratones Endogámicos mdx
Descriptor ratones endogámicos mdx
Entry term(s) ratones consanguíneos mdx
Scope note: Cepa de ratones que surgen por mutación espontánea (mdx) en ratones endogámicos C57BL. Esta mutación está ligada al cromosoma X y produce animales homocigóticos viables que no poseen distrofina, una proteína muscular, tienen altos niveles de enzimas musculares en el suero, y poseen lesiones histológicas similares a la distrofia muscular humana. Las características histológicas, nexos y posición del mapa de mdx hace que estos ratones sean un modelo animal inestimable en el estudio de la distrofia muscular de Duchenne.
Descriptor Portuguese: Camundongos Endogâmicos mdx
Descriptor French: Souris de lignée mdx
Entry term(s): Souris de souche mdx
Souris mdx
Tree number(s): B01.050.050.199.520.520.420.500
B01.050.150.900.649.313.992.635.505.500.400.420.500
B01.050.150.900.649.313.992.635.505.500.550.265
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018101
Scope note: A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.
Annotation: NIM with no qualifiers when experimental animal; check the tag MICE
Allowable Qualifiers: AB malformations
AH anatomie et histologie
BL sang
CF liquide cérébrospinal
CL classification
EM embryologie
GD croissance et développement
GE génétique
IM immunologie
IN traumatismes
ME métabolisme
MI microbiologie
PH physiologie
PS parasitologie
PX psychologie
SU chirurgie
UR urine
VI virologie
Related: Dystrophies musculaires MeSH
DeCS ID: 31309
Unique ID: D018101
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1994/01/01
Date of Entry: 1993/06/03
Revision Date: 2017/07/11
Souris de lignée mdx - Preferred
Concept UI M0027297
Preferred term Souris de lignée mdx
Entry term(s) Souris de souche mdx
Souris mdx



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