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Descriptor English: DNA Topoisomerases, Type I
Descriptor Spanish: ADN-Topoisomerasas de Tipo I
Descriptor ADN-topoisomerasas de tipo I
Entry term(s) ADN topoisomerasas de tipo I
ADN topoisomerasas de tipo I eucarióticas
ADN topoisomerasas tipo I
ADN-topoisomerasa III
ADN-topoisomerasa III alfa
ADN-topoisomerasa III beta
TOP3 alfa
TOPO III alfa
enzima desenrolladora del ADN
enzima relajante del ADN
enzimas desenrolladoras del ADN
proteína relajante del ADN
proteína selladora de muescas del ADN
proteínas desenrolladoras del ADN
topo III
topoisomerasa III
topoisomerasa III alfa
topoisomerasa III beta
topoisomerasa TOP3
topoisomerasas de ADN I eucarióticas
topoisomerasas de ADN tipo I eucarióticas
Scope note: Enzima que cataliza la ruptura independiente de ATP de una de las dos hebras de ADN, el paso de la otra hebra intacta a través de la ruptura y la unión de nuevo de la hebra rota. Las ADN topoisomerasas de tipo I reducen la tensión topológica en la estructura del ADN relajando las vueltas de superhélice y desenredando la hélice de ADN.
Descriptor Portuguese: DNA Topoisomerases Tipo I
Descriptor French: ADN topoisomérases de type I
Entry term(s): ADN topoisomérase-I d'archée
ADN topoisomérases type 1
DNA Topoisomerase I
Nicking-closing enzyme
Omega protéine
Relaxing enzyme
Swivelase
Type I DNA topoisomerases
untwisting enzyme
Tree number(s): D08.811.399.403.483
D12.776.157.687.375
D12.776.660.720.375
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004264
Scope note: DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
Annotation: do not confuse entry term DNA UNTWISTING PROTEIN with DNA UNWINDING PROTEINS see DNA HELICASES; coordinate with BACTERIAL PROTEINS or ARCHAEAL PROTEINS if pertinent
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Topoisomerase I Inhibitors
Registry Number: EC 5.99.1.2
CAS Type 1 Name: DNA topoisomerase
DeCS ID: 31732
Unique ID: D004264
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1977/04/15
Revision Date: 2019/07/08
ADN topoisomérases de type I - Preferred
Concept UI M0381011
Preferred term ADN topoisomérases de type I
Entry term(s) ADN topoisomérase-I d'archée
ADN topoisomérases type 1
DNA Topoisomerase I
Nicking-closing enzyme
Omega protéine
Relaxing enzyme
Swivelase
Type I DNA topoisomerases
untwisting enzyme



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