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Descriptor English: fas Receptor
Descriptor Spanish: Receptor fas
Descriptor receptor fas
Entry term(s) antígeno APO-1
antígeno CD95
antígeno fas
antígenos CD95
antígenos fas
miembro 6 de la superfamilia de receptores del factor de necrosis tumoral
receptor TNFRSF6
receptor de muerte de la superficie celular Fas
receptores fas
Scope note: Subtipo de receptor del factor de necrosis tumoral que se encuentra en varios tejidos y en los LINFOCITOS activados. Tiene especificidad por el LIGANDO FAS y desempeña un papel en la regulación de las respuestas inmunitarias periféricas y la APOPTOSIS. Existen múltiples isoformas debido al EMPALME ALTERNATIVO. El receptor activado señaliza a través de un dominio de muerte conservado que se asocia a FACTORES ASOCIADOS AL RECEPTOR DE TNF específicos en el CITOPLASMA. Las mutaciones en el gen CD92 se asocian a casos de síndrome linfoproliferativo autoinmunitario.
Descriptor Portuguese: Receptor fas
Descriptor French: Antigènes CD95
Entry term(s): APO 1 Antigen
APO-1 Antigen
Antigens, CD95
CD95 Antigen
CD95 Antigens
Fas Cell Surface Death Receptor
Receptor, TNFRSF6
Receptor, fas
Receptors, fas
TNFRSF6 Receptor
Tumor Necrosis Factor Receptor Superfamily, Member 6
fas Antigen
fas Antigens
fas Receptors
Tree number(s): D12.776.543.750.690.500
D12.776.543.750.705.852.760.195
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019014
Scope note: A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Antigens, Surface (1989-1995)
Public MeSH Note: 2018; see ANTIGENS, CD95 1989-2017; FAS ANTIGEN was indexed under ANTIGENS, SURFACE 1989-1995; FAS RECEPTOR was indexed under RECEPTORS, TUMOR NECROSIS FACTOR 1998-1999
History Note: 2018 (1989)
Entry Version: FAS RECEPT
Related: Autoimmune Lymphoproliferative Syndrome MeSH
DeCS ID: 32837
Unique ID: D019014
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2017/05/24
fas Receptor - Preferred
Concept UI M0028392
Scope note A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome.
Preferred term fas Receptor
Entry term(s) APO 1 Antigen
APO-1 Antigen
Antigens, CD95
CD95 Antigen
CD95 Antigens
Fas Cell Surface Death Receptor
Receptor, TNFRSF6
Receptor, fas
Receptors, fas
TNFRSF6 Receptor
Tumor Necrosis Factor Receptor Superfamily, Member 6
fas Antigen
fas Antigens
fas Receptors



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