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Descriptor English: | Disintegrins | ||||||
Descriptor Spanish: |
Desintegrinas
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Descriptor Portuguese: | Desintegrinas | ||||||
Descriptor French: | Désintégrines | ||||||
Tree number(s): |
D12.644.138 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019483 | ||||||
Scope note: | A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors. |
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Annotation: | polypeptides from snake venom; platelet aggregation inhib |
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Allowable Qualifiers: |
AD administration et posologie AE effets indésirables AG agonistes AI antagonistes et inhibiteurs AN analyse BI biosynthèse BL sang CF liquide cérébrospinal CH composition chimique CL classification CS synthèse chimique DE effets des médicaments et des substances chimiques DF déficit EC économie GE génétique HI histoire IM immunologie IP isolement et purification ME métabolisme PD pharmacologie PH physiologie PK pharmacocinétique PO intoxication RE effets des radiations SD ressources et distribution ST normes TO toxicité TU usage thérapeutique UR urine |
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Pharm Action: |
Platelet Aggregation Inhibitors |
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DeCS ID: | 33035 | ||||||
Unique ID: | D019483 | ||||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
Date Established: | 1997/01/01 | ||||||
Date of Entry: | 1996/06/10 | ||||||
Revision Date: | 2020/05/27 |
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PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Acides aminés, peptides et protéines [D12]Acides aminés, peptides et protéines
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