DeCS

Descriptor English:

Sirolimus

Descriptor Spanish:

Sirolimus

Spanish from Spain

Descriptor	sirólimus
Entry term(s)	rapamicina sirolimus
Scope note:	Compuesto macrólido obtenido de Streptomyces hygroscopicus que actúa bloqueando selectivamente la activación transcripcional de citocinas, inhibiendo por consiguiente la producción de citocinas. Es bioactivo sólamente cuando se encuentra unido a las INMUNOFILINAS. El sirolimús es un potente inmunosupresor y posee propiedades antifúngicas y antineoplásicas.

Descriptor Portuguese:

Sirolimo

Descriptor French:

Sirolimus

Entry term(s):

AY 22-989
AY-22989
AY22-989
AY22989
I-2190A
I2190A
Rapamycine

Tree number(s):

D02.540.505.760

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D020123

Scope note:

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Anti-Bacterial Agents
Antibiotics, Antineoplastic
Antifungal Agents
Immunosuppressive Agents

Registry Number:

W36ZG6FT64

DeCS ID:

33809

Unique ID:

D020123

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

1999/01/01