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Descriptor English: Vigabatrin
Descriptor Spanish: Vigabatrin
Descriptor vigabatrina
Entry term(s) ácido gamma-vinil-gamma-aminobutírico
Scope note: Análogo del ÁCIDO GAMMA-AMINOBUTÍRICO. Es un inhibidor irreversible de la 4-AMINOBUTIRATO TRANSAMINASA, la enzima responsable del catabolismo del ÁCIDO GAMMA-AMINOBUTÍRICO, y se utiliza como anticonvulsivo. (Traducción libre del original: Martindale The Extra Pharmacopoeia, 31st ed)
Descriptor Portuguese: Vigabatrina
Descriptor French: Vigabatrine
Entry term(s): Sabril
Sabrilex
gamma Vinyl GABA
gamma Vinyl gamma Aminobutyric Acid
gamma-Vinyl-GABA
gamma-Vinyl-gamma-Aminobutyric Acid
Tree number(s): D02.241.081.114.500.350.900
D12.125.190.350.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020888
Scope note: An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible for the catabolism of GAMMA-AMINOBUTYRIC ACID and is used as an anticonvulsant. (From Martindale The Extra Pharmacopoeia, 31st ed)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticonvulsants
Enzyme Inhibitors
GABA Agents
Registry Number: GR120KRT6K
CAS Type 1 Name: 4-Amino-5-hexenoic Acid
Previous Indexing: Aminocaproic Acids (1981-1994)
GABA/analogs & derivatives (1979-1980)
GABA/analogs & derivatives (1994-1999)
Public MeSH Note: 2000; VIGABATRIN was indexed under GABA/analogs & derivatives 1994-1999, AMINOCAPROIC ACIDS 1981-1994, & GABA/analogs 1979-1980
History Note: 2000; use VIGABATRIN 1977-1999
DeCS ID: 34388
Unique ID: D020888
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/04
Revision Date: 2018/05/21
Vigabatrin - Preferred
Concept UI M0328364
Scope note An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible for the catabolism of GAMMA-AMINOBUTYRIC ACID and is used as an anticonvulsant. (From Martindale The Extra Pharmacopoeia, 31st ed)
Preferred term Vigabatrin
Entry term(s) gamma Vinyl GABA
gamma Vinyl gamma Aminobutyric Acid
gamma-Vinyl-GABA
gamma-Vinyl-gamma-Aminobutyric Acid
Sabrilex - Narrower
Concept UI M000642495
Preferred term Sabrilex
Sabril - Narrower
Concept UI M0333927
Preferred term Sabril



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