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Descriptor English: MAP Kinase Signaling System
Descriptor Spanish: Sistema de Señalización de MAP Quinasas
Descriptor Portuguese: Sistema de Sinalização das MAP Quinases
Descriptor French: Système de signalisation des MAP kinases
Entry term(s): Cascade des MAP kinases
Cascade des MAPK
Cascades de signalisation des MAP kinases
Cascades de signalisation des MAPK
Système de signalisation des MAPK
Système des MAP kinases
Système des MAPK
Voie de la kinase p38
Voie de signalisation de la kinase p38
Voie de signalisation des JNK
Voie de transduction de signaux via les ERK
Voie des ERK
Voie des ERK1 et ERK2
Voie des ERK1-2
Voie des JNK
Voie des MEK-ERK
Voies de signalisation des MAP kinases
Voies de signalisation des MAPK
Voies des MAP kinases
Voies des MAPK
Tree number(s): G02.111.820.560
G03.493.560
G04.835.560
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020935
Scope note: An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Allowable Qualifiers: DE effets des médicaments et des substances chimiques
GE génétique
IM immunologie
PH physiologie
RE effets des radiations
Related: MAP Kinase Kinase Kinases MeSH
Mitogen-Activated Protein Kinase Kinases MeSH
Mitogen-Activated Protein Kinases MeSH
DeCS ID: 34468
Unique ID: D020935
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/05
Revision Date: 2016/06/23
Système de signalisation des MAP kinases - Preferred
Concept UI M0328035
Preferred term Système de signalisation des MAP kinases
Entry term(s) Système de signalisation des MAPK
Système des MAP kinases
Système des MAPK
Voie des ERK1-2 - Related but not broader or narrower
Concept UI M0555312
Preferred term Voie des ERK1-2
Entry term(s) Voie des ERK1 et ERK2
Voie de la kinase p38 - Narrower
Concept UI M0557375
Preferred term Voie de la kinase p38
Entry term(s) Voie de signalisation de la kinase p38
Cascade des MAP kinases - Narrower
Concept UI M0331442
Preferred term Cascade des MAP kinases
Entry term(s) Cascade des MAPK
Cascades de signalisation des MAP kinases
Cascades de signalisation des MAPK
Voies de signalisation des MAP kinases - Related but not broader or narrower
Concept UI M0331445
Preferred term Voies de signalisation des MAP kinases
Entry term(s) Voies de signalisation des MAPK
Voies des MAP kinases
Voies des MAPK
Voie des MEK-ERK - Narrower
Concept UI M0556022
Preferred term Voie des MEK-ERK
Voie de transduction de signaux via les ERK - Narrower
Concept UI M0556021
Preferred term Voie de transduction de signaux via les ERK
Entry term(s) Voie des ERK
Voie des JNK - Narrower
Concept UI M0557374
Preferred term Voie des JNK
Entry term(s) Voie de signalisation des JNK



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