DeCS

Descriptor English:

Cyclophosphamide

Descriptor Spanish:

Ciclofosfamida

Spanish from Spain

Descriptor

ciclofosfamida

Scope note:

Precursor de una mostaza nitrogenada alquilante, antineoplásica e inmunosupresora que es activada en el HÍGADO dando lugar a la forma activa aldofosfamida. Se ha utilizado en el tratamiento de LINFOMAS y LEUCEMIAS. Su efecto colateral, la ALOPECIA, ha sido aprovechado para el esquilado de las ovejas. La ciclofosfamida también puede producir esterilidad, malformaciones congénitas, mutaciones y cáncer.

Descriptor Portuguese:

Ciclofosfamida

Descriptor French:

Cyclophosphamide

Entry term(s):

B-518
B518
NSC-26271
NSC26271

Tree number(s):

D02.455.526.728.650.730.243
D02.705.672.500.243

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D003520

Scope note:

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Immunosuppressive Agents
Mutagens
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Myeloablative Agonists

Registry Number:

8N3DW7272P

DeCS ID:

3540

Unique ID:

D003520

NLM Classification:

QV 269

Documents indexed in the Virtual Health Library (VHL):

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