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Descriptor English: Cyclosporins
Descriptor Spanish: Ciclosporinas
Descriptor ciclosporinas
Scope note: Grupo de undecapéptidos cíclicos, estrechamente relacionados, de los hongos Trichoderma polysporum y Cylindocarpon lucidum. Tienen cierta acción antineoplásica y antifúngica, así como importantes efectos inmunosupresores. Se ha propuesto el uso de ciclosporina como adyuvantes en el trasplante de tejidos y órganos, a fin de evitar el rechazo del injerto.
Descriptor Portuguese: Ciclosporinas
Descriptor French: Cyclosporines
Entry term(s): Cyclosporines
Tree number(s): D04.345.566.235
D12.644.641.235
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003524
Scope note: A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Annotation: do not confuse with CYCLOSPORINE, a specific drug
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Enzyme Inhibitors
Immunosuppressive Agents
Previous Indexing: Immunosuppressive Agents (1966-1981)
Peptides (1966-1970)
Peptides, Cyclic (1971-1981)
Public MeSH Note: 82
History Note: 82
DeCS ID: 3544
Unique ID: D003524
NLM Classification: QW 920
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1982/01/01
Date of Entry: 1981/05/14
Revision Date: 2014/06/13
Cyclosporins - Preferred
Concept UI M0005493
Scope note A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Preferred term Cyclosporins
Entry term(s) Cyclosporines



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