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Descriptor English: Ubiquitin
Descriptor Spanish: Ubiquitina
Descriptor ubicuitina
Scope note: Polipéptido de 76 aminoácidos muy conservado que se encuentra en células eucariotas y actúa como marcador en el TRANSPORTE y la degradación de proteínas intracelulares. La ubicuitina se activa a través de una serie de pasos complejos y forma un enlace isopeptídico con residuos de lisina de proteínas específicas en el interior de la célula. Estas proteíns "ubicuitinadas" pueden ser reconocidas y degradadas por proteosomas o pueden ser transportadas a compartimientos específicos dentro de la célula.
Descriptor Portuguese: Ubiquitina
Descriptor French: Ubiquitine
Entry term(s): APF-1
ATP Dependent Proteolysis Factor 1
ATP-Dependent Proteolysis Factor 1
HMG-20
High Mobility Protein 20
Human Ubiquitin
Ubiquitin, Human
Tree number(s): D12.776.947.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D025801
Scope note: A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
Annotation: UBIQUITINS is also available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Chromosomal Proteins, Non-Histone (1977-1984)
Nucleoproteins (1966-1977)
Peptides (1975-1980)
Ubiquitins (1985-2001)
Public MeSH Note: 2002; see UBIQUITINS (1985-2001)
History Note: 2002; use UBIQUITINS (1985-2001)
DeCS ID: 36260
Unique ID: D025801
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2015/06/05
Ubiquitin - Preferred
Concept UI M0369737
Scope note A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
Preferred term Ubiquitin
Entry term(s) APF-1
ATP Dependent Proteolysis Factor 1
ATP-Dependent Proteolysis Factor 1
HMG-20
High Mobility Protein 20
Ubiquitin, Human - Narrower
Concept UI M0329583
Preferred term Ubiquitin, Human
Entry term(s) Human Ubiquitin



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