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Descriptor English: | Dactinomycin | ||||||
Descriptor Spanish: |
Dactinomicina
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Descriptor Portuguese: | Dactinomicina | ||||||
Descriptor French: | Dactinomycine | ||||||
Entry term(s): |
Actinomycine Actinomycine C1 Actinomycine D |
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Tree number(s): |
D03.633.300.200 D04.345.566.252 D12.644.641.252 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D003609 | ||||||
Scope note: | A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) |
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Allowable Qualifiers: |
AA analogues et dérivés AD administration et posologie AE effets indésirables AG agonistes AI antagonistes et inhibiteurs AN analyse BI biosynthèse BL sang CF liquide cérébrospinal CH composition chimique CL classification CS synthèse chimique EC économie HI histoire IM immunologie IP isolement et purification ME métabolisme PD pharmacologie PK pharmacocinétique PO intoxication RE effets des radiations SD ressources et distribution ST normes TO toxicité TU usage thérapeutique UR urine |
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Pharm Action: |
Anti-Bacterial Agents Antibiotics, Antineoplastic Protein Synthesis Inhibitors Nucleic Acid Synthesis Inhibitors |
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Registry Number: | 1CC1JFE158 | ||||||
CAS Type 1 Name: | Actinomycin D | ||||||
DeCS ID: | 3628 | ||||||
Unique ID: | D003609 | ||||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
Date Established: | 1966/01/01 | ||||||
Date of Entry: | 1999/01/01 | ||||||
Revision Date: | 2017/05/24 |
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PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Composés hétérocycliques [D03]Composés hétérocycliques -
PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Composés polycycliques [D04]Composés polycycliques -
PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Acides aminés, peptides et protéines [D12]Acides aminés, peptides et protéines
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Dactinomycine
- Preferred
Actinomycine
- Broader
Concept UI |
M0005644 |
Preferred term | Dactinomycine |
Entry term(s) |
Actinomycine C1 Actinomycine D |
Concept UI |
M0005643 |
Preferred term | Actinomycine |
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