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Descriptor English: Dactinomycin
Descriptor Spanish: Dactinomicina
Descriptor dactinomicina
Entry term(s) actinomicina
actinomicina D
meractinomicina
Scope note: Sustancia compuesta por dos PÉPTIDOS CÍCLICOS unidos a la fenoxazina, que deriva del STREPTOMYCES parvullus. Se une al ADN e inhibe la síntesis de ARN (transcripción), con la elongación de la cadena más sensible que la iniciación, la terminación o extensión. Como resultado de la producción alterada de ARNm, la síntesis proteica también declina después del tratamiento con dactinomicina (de AMA Drug Evaluations Annual, 1993, p2015).
Descriptor Portuguese: Dactinomicina
Descriptor French: Dactinomycine
Entry term(s): Actinomycine
Actinomycine C1
Actinomycine D
Tree number(s): D03.633.300.200
D04.345.566.252
D12.644.641.252
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003609
Scope note: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Anti-Bacterial Agents
Antibiotics, Antineoplastic
Protein Synthesis Inhibitors
Nucleic Acid Synthesis Inhibitors
Registry Number: 1CC1JFE158
CAS Type 1 Name: Actinomycin D
DeCS ID: 3628
Unique ID: D003609
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Dactinomycine - Preferred
Concept UI M0005644
Preferred term Dactinomycine
Entry term(s) Actinomycine C1
Actinomycine D
Actinomycine - Broader
Concept UI M0005643
Preferred term Actinomycine



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