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Descriptor English: Sirtuins
Descriptor Spanish: Sirtuinas
Descriptor sirtuinas
Entry term(s) SIRT
SIRTs
proteínas similares a Sir2
sirtuína
Scope note: Familia de enzimas reguladoras homólogas, estructuralmente relacionadas con la proteína 2 reguladora de información silente del tipo sexual (Sir2), que se encuentra en Saccharomyces cerevisiae. Las sirtuinas contienen una región central catalítica que se une a NAD. Varias sirtuinas utilizan NAD para desacetilar proteínas, como las HISTONAS, y se clasifican como HISTONA DESACETILASAS DEL GRUPO III. Otros miembros de la familia de las sirtuinas utilizan el NAD para transferir ADP-RIBOSA a proteínas y se clasifican como MONO ADP-RIBOSA TRANSFERASAS y un tercer grupo parecen tener actividad desacetilasa y ADP ribosa transferasa.
Descriptor Portuguese: Sirtuínas
Descriptor French: Sirtuines
Entry term(s): Protéines Sir2-like
SIRT
Tree number(s): D08.811.277.087.520.200.650
D08.811.913.400.725.115.961
D12.776.476.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D037761
Scope note: A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Registry Number: EC 3.5.1.-
Related: Protéines SIR de Saccharomyces cerevisiae MeSH
DeCS ID: 37322
Unique ID: D037761
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2020/05/27
Sirtuines - Preferred
Concept UI M0413549
Preferred term Sirtuines
Entry term(s) Protéines Sir2-like
SIRT



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