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Descriptor English: RNA, Small Interfering
Descriptor Spanish: ARN Interferente Pequeño
Descriptor ARN interferente pequeño
Entry term(s) ARN de reconocimiento
escáner de pequeño ARN
siARN asociado con repetición
siARN trans-actuante
siARN transactivador
siRNA
siRNA asociado a repeticiones
Scope note: Pequeños ARN bicatenarios no codificadores de proteínas, de 21 A 31 nucleótidos, que intervienen en mecanismos de SILENCIAMIENTO GÉNICO, especialmente en la INTERFERENCIA POR ARN (iRNA). Los ARN interferentes pequeños (siRNA) se forman endógenamente a partir de dsRNA (ARN BICATENARIOS) por acción de una misma ribonucleasa, Dícer, que genera miRNA(MICROARN). El apareamiento perfecto de la hebra antiparalela de los ARNsi con ARN complementarios interviene en la interferencia por ARN mediante la escisión del ARN guiada por el ARNsi. Los ARNsi se clasifican en: siRNA que actúan en trans (tasiRNA), ARN asociados a repeticiones (rasiRNA), ARN de reconocimiento pequeño (scnRNA) y ARN de interacción con proteínas Piwi (piRNA), y desempeñan diversas funciones específicas de silenciamiento génico.
Descriptor Portuguese: RNA Interferente Pequeno
Descriptor French: Petit ARN interférent
Entry term(s): Hairpin RNA, Short
Hairpin RNA, Small
Interfering RNA, Short
Interfering RNA, Small
RNA, Scan
RNA, Short Hairpin
RNA, Short Interfering
RNA, Small Hairpin
RNA, Small Scan
Repeat Associated siRNA
Repeat-Associated siRNA
Scan RNA
Scan RNA, Small
Short Hairpin RNA
Short Interfering RNA
Small Hairpin RNA
Small Interfering RNA
Small Scan RNA
Trans Acting siRNA
Trans-Acting siRNA
scnRNA
shRNA
siRNA
siRNA, Repeat Associated
siRNA, Repeat-Associated
siRNA, Trans Acting
siRNA, Trans-Acting
tasiRNA
Tree number(s): D13.150.650.700
D13.444.735.150.700
D13.444.735.790.552.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D034741
Scope note: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Annotation: Do not confuse with defective interfering RNA (diRNA), a viral RNA of DEFECTIVE VIRUSES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2003; RNA, SMALL INTERFERING was indexed under RNA, UNTRANSLATED 2001-2002
History Note: 2003; use RNA, SMALL INTERFERING (NM) 2001-2002
Related: MicroRNAs MeSH
RNA Interference MeSH
RNA-Induced Silencing Complex MeSH
DeCS ID: 37536
Unique ID: D034741
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2010/06/25
RNA, Small Interfering - Preferred
Concept UI M0406100
Scope note Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Preferred term RNA, Small Interfering
Entry term(s) Interfering RNA, Short
Interfering RNA, Small
RNA, Short Interfering
Short Interfering RNA
Small Interfering RNA
siRNA
Short Hairpin RNA - Narrower
Concept UI M0543638
Preferred term Short Hairpin RNA
Entry term(s) Hairpin RNA, Short
Hairpin RNA, Small
RNA, Short Hairpin
RNA, Small Hairpin
Small Hairpin RNA
shRNA
Repeat-Associated siRNA - Related but not broader or narrower
Concept UI M0507096
Scope note siRNAs involved with GENE SILENCING of MOBILE GENETIC ELEMENTS in DROSOPHILA.
Preferred term Repeat-Associated siRNA
Entry term(s) Repeat Associated siRNA
siRNA, Repeat Associated
siRNA, Repeat-Associated
Scan RNA - Narrower
Concept UI M0507095
Scope note siRNAs, found in TETRAHYMENA, that are homologous to internal eliminated sequences (IESs) deleted during programmed genome rearrangement.
Preferred term Scan RNA
Entry term(s) RNA, Scan
RNA, Small Scan
Scan RNA, Small
Small Scan RNA
scnRNA
Trans-Acting siRNA - Narrower
Concept UI M0507097
Scope note siRNA, found in plants, that are involved in silencing different gene loci than those from which they were derived.
Preferred term Trans-Acting siRNA
Entry term(s) Trans Acting siRNA
siRNA, Trans Acting
siRNA, Trans-Acting
tasiRNA



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