You have selected the view in French

Descriptor English:

Digoxin

Descriptor Spanish:

Digoxina

Spanish from Spain

Descriptor

digoxina

Scope note:

Glicósido cardiotónico que se obtiene principalmente de la Digitalis lanata. Consta de tres azúcares y de una aglicona, la DIGOXIGENINA. La digoxina tiene actividad inotrópica positiva y cronotrópica negativa. Se usa para controlar la frecuencia ventricular en la FIBRILACIÓN AURICULAR y en el tratamiento de la insuficiencia cardíaca congestiva con fibrilación auricular. Su uso en la insuficiencia cardíaca congestiva con ritmo sinusal está menos comprobado. El margen entre la dosis tóxica y la terapéutica es pequeño. (Martindale, The Extra Pharmacopoeia, 30th ed, p666)

Descriptor Portuguese:

Digoxina

Descriptor French:

Digoxine

Tree number(s):

D04.210.500.155.580.130.500.436
D04.210.500.155.580.130.688
D09.408.180.261.436

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D004077

Scope note:

A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)

Annotation:

do not confuse with DIGITOXIN

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Anti-Arrhythmia Agents
Cardiotonic Agents
Enzyme Inhibitors

Registry Number:

73K4184T59

CAS Type 1 Name:

Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-

DeCS ID:

4116

Unique ID:

D004077

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

1966/01/01

Date of Entry:

1999/01/01

Revision Date:

2017/05/24