DeCS

Descriptor English:

Doxepin

Descriptor Spanish:

Doxepina

Spanish from Spain

Descriptor

doxepina

Scope note:

Compuesto tricíclico de dibenzoxepina. Muestra una gama de acciones farmacológicas que incluyen el mantenimiento de la inervación adrenérgica. Su mecanismo de acción no está del todo comprendido, pero parece que bloquea la recaptación de neurotransmisores monoaminérgicos en las terminales presinápticas. Posee también actividad anticolinérgica y modula el antagonismo de los receptores de histamina H(1)- y H(2)-.

Descriptor Portuguese:

Doxepina

Descriptor French:

Doxépine

Entry term(s):

Chlorhydrate de doxépine

Tree number(s):

D02.355.291.852.500
D03.633.300.382.393

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D004316

Scope note:

A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Sleep Aids, Pharmaceutical
Antidepressive Agents, Tricyclic
Histamine Antagonists

Registry Number:

1668-19-5

CAS Type 1 Name:

1-Propanamine, 3-dibenz(b,e)oxepin-11(6H)-ylidene-N,N-dimethyl-

DeCS ID:

4375

Unique ID:

D004316

Documents indexed in the Virtual Health Library (VHL):

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