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Descriptor English: Drug Tolerance
Descriptor Spanish: Tolerancia a Medicamentos
Descriptor tolerancia a medicamentos
Entry term(s) tolerancia a fármacos
tolerancia farmacológica
tolerancia medicamentosa
Scope note: Disminución progresiva de la sensibilidad de los seres humanos o los animales a los efectos de un fármaco, debido a su administración continuada. Se debe diferenciar de la FARMACORRESISTENCIA, en la que el organismo, la enfermedad o un tejido no responden en la adecuada medida a la sustancia química o al fármaco. Debe diferenciarse también de la DOSIS MÁXIMA TOLERADA y de la DOSIS SIN EFECTOS ADVERSOS OBSERVADOS.
Descriptor Portuguese: Tolerância a Medicamentos
Descriptor French: Tolérance aux médicaments
Entry term(s): Drug Tolerances
Tolerance, Drug
Tolerances, Drug
Tree number(s): G07.690.773.992
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004361
Scope note: Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
Annotation: differentiate from DRUG RESISTANCE; not for tolerability ( = drug /adv eff): Manual 28.19
Allowable Qualifiers: EH ethnology
GE genetics
IM immunology
PH physiology
RE radiation effects
DeCS ID: 4420
Unique ID: D004361
NLM Classification: QV 37
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/06/29
Drug Tolerance - Preferred
Concept UI M0006854
Scope note Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
Preferred term Drug Tolerance
Entry term(s) Drug Tolerances
Tolerance, Drug
Tolerances, Drug



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