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Descriptor English: Squalene Monooxygenase
Descriptor Spanish: Escualeno-Monooxigenasa
Descriptor escualeno-monooxigenasa
Entry term(s) escualeno monooxigenasa
Scope note: Segunda enzima en la vía encargada de la biosíntesis del COLESTEROL. Esta enzima cataliza la primera etapa de oxigenación en la biosíntesis de ESTEROLES y se cree que es una enzima limitante de la velocidad en esta vía. Específicamente, cataliza la converisón de ESCUALENO a (S)-escualeno-2,3-epóxido.
Descriptor Portuguese: Esqualeno Mono-Oxigenase
Descriptor French: Squalene monooxygenase
Entry term(s): Epoxidase, Squalene
Monooxygenase, Squalene
Squalene Epoxidase
Squalene Monooxygenase (2,3-Epoxidizing)
Tree number(s): D08.811.682.690.708.749
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050603
Scope note: The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.14.14.17
Public MeSH Note: 2006; SQUALENE MONOOXYGENASE was indexed under OXYGENASES 1981-2005 & ETHERS, CYCLIC 1970-1980
History Note: 2006(1980); use ETHERS, CYCLIC 1970-1979
DeCS ID: 50664
Unique ID: D050603
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2016/06/01
Squalene Monooxygenase - Preferred
Concept UI M0079002
Scope note The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
Preferred term Squalene Monooxygenase
Entry term(s) Epoxidase, Squalene
Monooxygenase, Squalene
Squalene Epoxidase
Squalene Monooxygenase (2,3-Epoxidizing)



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