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Descriptor English: Granzymes
Descriptor Spanish: Granzimas
Descriptor granzimas
Scope note: Familia de serina endopeptidasas que se encuentran en los GRÁNULOS SECRETORES de los LEUCOCITOS como los LINFOCITOS T CITOTÓXICOS y CÉLULAS ASESINAS NATURALES. Cuando se segregan al espacio intercelular las granzimas actúan eliminando las células huésped transformadas e infectadas por virus.
Descriptor Portuguese: Granzimas
Descriptor French: Granzymes
Entry term(s): Cytotoxic T-lymphocyte proteinase 1
Cytotoxic serine protease B
Facteur Hanukah
Fragmentin 2
Granzyme
Granzyme 3
Granzyme A
Granzyme B
Granzyme C
Granzyme K
Granzyme M
Granzyme-3
NK-Tryptase-2
Natural killer cell granule tryptase-2
Protéine 1 associée aux lymphocytes T cytotoxiques
Sérine-protéase cytotoxique B
Tree number(s): D08.811.277.656.300.760.397
D08.811.277.656.959.350.397
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053804
Scope note: A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Pharm Action: Cytotoxins
Registry Number: EC 3.4.21.-
DeCS ID: 52244
Unique ID: D053804
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2009/07/06
Granzymes - Preferred
Concept UI M0496635
Preferred term Granzymes
Entry term(s) Granzyme
Granzyme M - Narrower
Concept UI M0352923
Preferred term Granzyme M
Granzyme C - Narrower
Concept UI M0153862
Preferred term Granzyme C
Granzyme K - Narrower
Concept UI M0210456
Preferred term Granzyme K
Entry term(s) Granzyme 3
Granzyme-3
NK-Tryptase-2
Natural killer cell granule tryptase-2
Granzyme A - Narrower
Concept UI M0456799
Preferred term Granzyme A
Entry term(s) Cytotoxic T-lymphocyte proteinase 1
Facteur Hanukah
Granzyme B - Narrower
Concept UI M0168804
Preferred term Granzyme B
Entry term(s) Cytotoxic serine protease B
Fragmentin 2
Protéine 1 associée aux lymphocytes T cytotoxiques
Sérine-protéase cytotoxique B



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