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Descriptor English: | Perforin | ||||||
Descriptor Spanish: |
Perforina
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Descriptor Portuguese: | Perforina | ||||||
Descriptor French: | Perforine | ||||||
Entry term(s): |
Cytolysine Perforine-1 Protéine formant des pores membranaires dans les lymphocytes Protéine formant les pores des lymphocytes |
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Tree number(s): |
D12.776.543.695.875 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D054353 | ||||||
Scope note: | A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell. |
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Allowable Qualifiers: |
AD administration et posologie AE effets indésirables AG agonistes AI antagonistes et inhibiteurs AN analyse BI biosynthèse BL sang CF liquide cérébrospinal CH composition chimique CL classification CS synthèse chimique DE effets des médicaments et des substances chimiques DF déficit EC économie GE génétique HI histoire IM immunologie IP isolement et purification ME métabolisme PD pharmacologie PH physiologie PK pharmacocinétique PO intoxication RE effets des radiations SD ressources et distribution ST normes TO toxicité TU usage thérapeutique UL ultrastructure UR urine |
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Pharm Action: |
Cytotoxins |
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Registry Number: | 126465-35-8 | ||||||
DeCS ID: | 52798 | ||||||
Unique ID: | D054353 | ||||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
Date Established: | 2008/01/01 | ||||||
Date of Entry: | 2007/07/09 | ||||||
Revision Date: | 2008/07/08 |
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PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Acides aminés, peptides et protéines [D12]Acides aminés, peptides et protéines
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Perforine
- Preferred
Concept UI |
M0133732 |
Preferred term | Perforine |
Entry term(s) |
Cytolysine Perforine-1 Protéine formant des pores membranaires dans les lymphocytes Protéine formant les pores des lymphocytes |
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