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Descriptor English: Cathepsin K
Descriptor Spanish: Catepsina K
Descriptor catepsina K
Scope note: Cisteína proteasa altamente expresada en los OSTEOCLASTOS que desempeña un papel fundamental en la REABSORCIÓN ÓSEA, como una potente enzima que degrada la MATRIZ EXTRACELULAR. 
Descriptor Portuguese: Catepsina K
Descriptor French: Cathepsine K
Tree number(s): D08.811.277.656.224.405
D08.811.277.656.262.500.156
D08.811.277.656.300.200.156
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D056657
Scope note: A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
Annotation: Cathepsin X, an obsolete multi-meaning term appearing in older literature goes here or at CATHEPSIN Z: check text; Cathepsin O and Cathepsin O2 in older literature go here.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.22.38
Public MeSH Note: 2010; CATHEPSIN K was indexed under CATHEPSINS 1984-2009
History Note: 2010(1984)
DeCS ID: 53600
Unique ID: D056657
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Cathepsin K - Preferred
Concept UI M0528260
Scope note A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
Preferred term Cathepsin K



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