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Descriptor English: CLOCK Proteins
Descriptor Spanish: Proteínas CLOCK
Descriptor proteínas CLOCK
Scope note: Proteínas que contiene dominios hélice-asa-hélice básicos (bHLH), poseen actividad HISTONA ACETILTRANSFERASA intrínseca y juegan un importante papel en la regulación del RITMO CIRCADIANO. Las proteínas CLOCK se combinan con proteínas Arntl formando factores de transcripción heterodiméricos, específicos de ELEMENTOS E-BOX y estimulan la transcripción de varios genes de caja E (E-box) implicados en la regulación cíclica. Esta activación transcripcional también pone en marcha un asa de retroalimentación dependiente del tiempo que efectúa una disminución regulada de proteínas clock.
Descriptor Portuguese: Proteínas CLOCK
Descriptor French: Protéines CLOCK
Entry term(s): CLOCK Protein
Circadian Locomotor Output Cycles Kaput Proteins
Tree number(s): D08.811.913.050.134.415.500.049
D12.644.360.138.100
D12.776.260.103.562
D12.776.476.156.200
D12.776.930.125.562
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D056926
Scope note: Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.3.1.48
Public MeSH Note: 2010; CLOCK PROTEIN (now CLOCK PROTEINS) was indexed under TRANSACTIVATORS 1997-2009
History Note: 2010(1997)
DeCS ID: 53609
Unique ID: D056926
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2018/06/30
CLOCK Proteins - Preferred
Concept UI M0533475
Scope note Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
Preferred term CLOCK Proteins
Entry term(s) CLOCK Protein
Circadian Locomotor Output Cycles Kaput Proteins



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