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Descriptor English: Simeprevir
Descriptor Spanish: Simeprevir
Descriptor simeprevir
Scope note: INHIBIDOR DE PROTEASA del VHC que se administra por vía oral, eficaz contra la serina proteasa NS3/4A del virus de la hepatitis C. Se utiliza en el tratamiento de la infección por el genotipo 1 de la hepatitis crónica C (Antivirales) en adultos con enfermedad hepática compensada, incluyendo la CIRROSIS.
Descriptor Portuguese: Simeprevir
Descriptor French: Siméprévir
Entry term(s): TMC-435
TMC-435350
TMC435
TMC435350
Tree number(s): D02.886.590.700.700
D03.633.300.819
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000069616
Scope note: Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS.
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Antiviral Agents
Protease Inhibitors
Registry Number: 9WS5RD66HZ
DeCS ID: 55903
Unique ID: D000069616
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/10
Revision Date: 2016/05/31
Siméprévir - Preferred
Concept UI M0526124
Preferred term Siméprévir
TMC-435350 - Narrower
Concept UI M0526125
Preferred term TMC-435350
Entry term(s) TMC435350
TMC-435 - Narrower
Concept UI M0542310
Preferred term TMC-435
Entry term(s) TMC435



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