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Descriptor English: Abatacept
Descriptor Spanish: Abatacept
Descriptor abatacept
Scope note: Una proteína de fusión compuesta por un inmunoconjugado del dominio extracelular de CTLA4 y el dominio Fc de la IgG1 humana. Funciona como un bloqueador de coestimulación de linfocitos T que inhibe el TNF-ALFA y previene la activación de los LINFOCITOS T. Se utiliza en el tratamiento de la ARTRITIS REUMATOIDE.
Descriptor Portuguese: Abatacepte
Descriptor French: Abatacept
Entry term(s): BMS 188667
BMS-188667
BMS-224818
BMS224818
Belatacept
Bélatacept
CTLA-4-Ig
CTLA4-Fc
CTLA4-Ig
Cytotoxic T lymphocyte-associated antigen 4-immunoglobulin
Immunoconjugué CTLA4-Ig
Nulojix
Tree number(s): D12.776.124.790.651.114.580.225
D12.776.377.715.548.114.580.225
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000069594
Scope note: A fusion protein immunoconjugate of the extracellular domain of CTLA4 and the Fc domain of human IgG1. It functions as a T-cell co-stimulation blocker that inhibits TNF-ALPHA and prevents the activation of T-LYMPHOCYTES. It is used in the treatment of RHEUMATOID ARTHRITIS.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
DE effets des médicaments et des substances chimiques
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Pharm Action: Immunosuppressive Agents
Antirheumatic Agents
Registry Number: 7D0YB67S97
Related: Antigène CTLA-4 MeSH
DeCS ID: 55984
Unique ID: D000069594
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2017/06/07
Abatacept - Preferred
Concept UI M0442852
Preferred term Abatacept
BMS224818 - Narrower
Concept UI M0498619
Preferred term BMS224818
Entry term(s) BMS-224818
Bélatacept - Narrower
Concept UI M0498618
Preferred term Bélatacept
Entry term(s) Belatacept
BMS 188667 - Narrower
Concept UI M0498617
Preferred term BMS 188667
Entry term(s) BMS-188667
CTLA-4-Ig - Narrower
Concept UI M0498620
Preferred term CTLA-4-Ig
Entry term(s) CTLA4-Fc
CTLA4-Ig
Cytotoxic T lymphocyte-associated antigen 4-immunoglobulin
Immunoconjugué CTLA4-Ig
Nulojix - Narrower
Concept UI M0568539
Preferred term Nulojix



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