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Descriptor English: A549 Cells
Descriptor Spanish: Células A549
Descriptor células A549
Entry term(s) línea celular A549
Scope note: Línea celular inmortal derivada de un ADENOCARCINOMA humano. Se trata de células epiteliales basales ALVEOLARES aisladas a partir de los pulmones de un paciente varón en 1972. Esta línea celular es positiva para la QUERATINA, puede sintetizar LECITINA y contiene altos niveles de ÁCIDOS GRASOS POLIINSATURADOS en su MEMBRANA PLASMÁTICA. Se utiliza como modelo para las infecciones virales y la función de los ALVEOLOS PULMONARES, como hospedador de TRANSFECCIÓN y para la EVALUACIÓN PRECLÍNICA DE FÁRMACOS.
Descriptor Portuguese: Células A549
Descriptor French: Cellules A549
Entry term(s): A549 Cell
A549 Cell Line
A549 Cell Lines
Cell Line, A549
Cell Lines, A549
Cell, A549
Cells, A549
Tree number(s): A11.251.210.190.080
A11.251.860.180.080
A11.436.054
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072283
Scope note: An immortalized cell line derived from human ADENOCARCINOMA, ALVEOLAR basal epithelial cells isolated from the lungs of a male patient in 1972. The cell line is positive for KERATIN, can synthesize LECITHIN, and contains high levels of POLYUNSATURATED FATTY ACIDS in its PLASMA MEMBRANE. It is used as a model for PULMONARY ALVEOLI function and virus infections, as a TRANSFECTION host, and for PRECLINICAL DRUG EVALUATION.
Annotation: almost always NIM with no subheadings; check HUMAN; do not routinely add ADENOCARCINOMA, ALVEOLAR
Allowable Qualifiers: CH chemistry
CL classification
CY cytology
DE drug effects
EN enzymology
IM immunology
ME metabolism
MI microbiology
PA pathology
PH physiology
PS parasitology
RE radiation effects
TR transplantation
UL ultrastructure
VI virology
Previous Indexing: Adenocarcinoma, Bronchiolo-Alveolar (1980-2016)
Cell Line (1980-2016)
Cell Line, Tumor (2004-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56270
Unique ID: D000072283
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/06/14
A549 Cells - Preferred
Concept UI M000616746
Scope note An immortalized cell line derived from human ADENOCARCINOMA, ALVEOLAR basal epithelial cells isolated from the lungs of a male patient in 1972. The cell line is positive for KERATIN, can synthesize LECITHIN, and contains high levels of POLYUNSATURATED FATTY ACIDS in its PLASMA MEMBRANE. It is used as a model for PULMONARY ALVEOLI function and virus infections, as a TRANSFECTION host, and for PRECLINICAL DRUG EVALUATION.
Preferred term A549 Cells
Entry term(s) A549 Cell
A549 Cell Line
A549 Cell Lines
Cell Line, A549
Cell Lines, A549
Cell, A549
Cells, A549



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