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Descriptor English: Werner Syndrome Helicase
Descriptor Spanish: Helicasa del Síndrome de Werner
Descriptor helicasa del síndrome de Werner
Entry term(s) helicasa dependiente de ATP del síndrome de Werner
helicasa tipo RecQ del síndrome de Werner
proteína RECQ3
proteína RECQL2
Scope note: Helicasa y exonucleasa 3'-5' dependiente de ADN. Tiene actividad exonucleasa 3'->5' hacia el ADN bicatenario con un 5'-que sobresale y se une preferentemente a sustratos de ADN que contienen estructuras secundarias alternativas, tales como empalmes de replicación y uniones holliday (vea ADN CRUCIFORME). Mutaciones en el gen WRN están asociadas con el SÍNDROME DE WERNER.
Descriptor Portuguese: Helicase da Síndrome de Werner
Descriptor French: Werner syndrome helicase
Entry term(s): Hélicase ATP-dépendante du syndrome de Werner
Hélicase du syndrome de Werner
Hélicase du syndrome de Werner semblable à RecQ
Protéine RECQ3
Protéine RECQL2
Tree number(s): D08.811.277.040.025.159.249.500
D08.811.277.352.335.375.875
D08.811.277.352.365.290.500
D08.811.399.340.249.500
D12.776.157.687.750
D12.776.660.720.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071657
Scope note: A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Registry Number: EC 3.6.4.12
DeCS ID: 56469
Unique ID: D000071657
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2017/05/24
Werner syndrome helicase - Preferred
Concept UI M000615275
Preferred term Werner syndrome helicase
Entry term(s) Hélicase ATP-dépendante du syndrome de Werner
Hélicase du syndrome de Werner
Hélicase du syndrome de Werner semblable à RecQ
Protéine RECQ3
Protéine RECQL2



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