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| Descriptor English: | Kelch-Like ECH-Associated Protein 1 | ||||||
| Descriptor Spanish: |
Proteína 1 Asociada A ECH Tipo Kelch
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| Descriptor Portuguese: | Proteína 1 Associada a ECH Semelhante a Kelch | ||||||
| Descriptor French: | Protéine-1 de type kelch associée à ECH | ||||||
| Entry term(s): |
KEAP 1 Protein KEAP-1 Protein KEAP1 Protein Kelch Like ECH Associated Protein 1 |
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| Tree number(s): |
D12.644.360.024.306 D12.776.157.057.067 D12.776.476.024.387 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000072019 | ||||||
| Scope note: | An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Adaptor Proteins, Signal Transducing (2005-2016) Carrier Proteins (1999-2016) Intracellular Signaling Peptides and Proteins (2004-2016) |
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| Public MeSH Note: | 2017 |
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| History Note: | 2017 |
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| DeCS ID: | 56536 | ||||||
| Unique ID: | D000072019 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/05/27 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Kelch-Like ECH-Associated Protein 1
- Preferred
| Concept UI |
M000616243 |
| Scope note | An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS. |
| Preferred term | Kelch-Like ECH-Associated Protein 1 |
| Entry term(s) |
KEAP 1 Protein KEAP-1 Protein KEAP1 Protein Kelch Like ECH Associated Protein 1 |
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