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Descriptor English: COP9 Signalosome Complex
Descriptor Spanish: Complejo del Señalosoma COP9
Descriptor complejo del señalosoma COP9
Entry term(s) Sgn3
proteína FUSCA 11
señalosoma COP9
señalosoma COP9 (CSN)
señalosoma de la fotomorfogénesis constitutiva 9
subunidad 1 del señalosoma COP9
subunidad 3 del señalosoma
subunidad 3 del señalosoma COP9
subunidad 4 del señalosoma COP9
subunidad 5 del señalosoma COP9
subunidad 6 del señalosoma COP9
subunidad 7A del señalosoma COP9
subunidad 7B del señalosoma COP9
subunidad 8 del señalosoma COP9
supresor 1 de la vía de la proteína G
Scope note: Complejo multiproteico que funciona como una peptidohidrolasa, o isopeptidasa, para el clivaje de la PROTEÍNA NEDD8 de las PROTEÍNAS CULLIN y de las UBIQUITINA-PROTEÍNA LIGASAS, con lo que controla la actividad de las ligasas. Está muy conservado en los eucariotas y típicamente consta de 8 subunidades (proteínas CSN 1-8). El señalosoma COP9 fue identificado originalmente en plantas, donde controla la transcripción genética como respuesta a la luz.
Descriptor Portuguese: Complexo do Signalossomo COP9
Descriptor French: Complexe du signalosome COP9
Entry term(s): COP9 Signalosome (CSN)
COP9 Signalosome Subunit 1
COP9 Signalosome Subunit 2
COP9 Signalosome Subunit 3
COP9 Signalosome Subunit 4
COP9 Signalosome Subunit 5
COP9 Signalosome Subunit 6
COP9 Signalosome Subunit 7A
COP9 Signalosome Subunit 7B
COP9 Signalosome Subunit 8
COP9 Signalsome
Constitutive Photomorphogenesis 9 Signalosome
Constitutive Photomorphogenesis 9 Signalsome
FUSCA Protein 11
G Protein Pathway Suppressor 1
Sgn3
Signalosome Complex, COP9
Signalosome Subunit 3
Signalsome, COP9
Subunit 3, Signalosome
Tree number(s): D05.500.139
D08.811.037.750.250
D08.811.277.656.300.887.375
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000075686
Scope note: A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.19.12
Public MeSH Note: 2018; COP9 SIGNALOSOME COMPLEX was indexed under PEPTIDE HYDROLASES and MULTIPROTEIN COMPLEXES 2006-207; under PROTEINS 1995-2005; and under PLANT PROTEINS 1995-1999; for COP9 SIGNALOSOME SUBUNIT 3 see SIGNALOSOME SUBUNIT 3 1998-2017; SIGNALOSOME SUBUNIT 3 was indexed under NUCLEAR PROTEINS and PROTEIN KINASES 1998-2017
History Note: 2018 (1995); for COP9 SIGNALOSOME SUBUNIT 3 use SIGNALOSOME SUBUNIT 3 1998-2017
DeCS ID: 56980
Unique ID: D000075686
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
COP9 Signalosome Complex - Preferred
Concept UI M0234074
Scope note A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.
Preferred term COP9 Signalosome Complex
Entry term(s) COP9 Signalosome (CSN)
COP9 Signalsome
Constitutive Photomorphogenesis 9 Signalosome
Constitutive Photomorphogenesis 9 Signalsome
Signalosome Complex, COP9
Signalsome, COP9
COP9 Signalosome Subunit 4 - Narrower
Concept UI M000631120
Preferred term COP9 Signalosome Subunit 4
COP9 Signalosome Subunit 5 - Narrower
Concept UI M000631121
Preferred term COP9 Signalosome Subunit 5
COP9 Signalosome Subunit 6 - Narrower
Concept UI M000631122
Preferred term COP9 Signalosome Subunit 6
COP9 Signalosome Subunit 2 - Narrower
Concept UI M000631118
Preferred term COP9 Signalosome Subunit 2
COP9 Signalosome Subunit 7B - Narrower
Concept UI M000631124
Preferred term COP9 Signalosome Subunit 7B
COP9 Signalosome Subunit 8 - Narrower
Concept UI M000631125
Preferred term COP9 Signalosome Subunit 8
COP9 Signalosome Subunit 1 - Narrower
Concept UI M000631117
Preferred term COP9 Signalosome Subunit 1
Entry term(s) G Protein Pathway Suppressor 1
COP9 Signalosome Subunit 3 - Narrower
Concept UI M000631119
Preferred term COP9 Signalosome Subunit 3
Entry term(s) FUSCA Protein 11
Sgn3
Signalosome Subunit 3
Subunit 3, Signalosome
COP9 Signalosome Subunit 7A - Narrower
Concept UI M000631123
Preferred term COP9 Signalosome Subunit 7A



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