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| Descriptor English: | High-Temperature Requirement A Serine Peptidase 2 | ||||||
| Descriptor Spanish: |
Serina Peptidasa A2 que Requiere Temperaturas Altas
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| Descriptor Portuguese: | Serina Peptidase 2 de Requerimento de Alta Temperatura A | ||||||
| Descriptor French: | High-temperature requirement A serine peptidase 2 | ||||||
| Entry term(s): |
HTRA2, Serine Protease High Temperature Requirement A Serine Peptidase 2 HtrA Serine Peptidase 2 HtrA2 Protease Omi Serine Protease Omi, Serine Protease Protease HTRA2, Serine Protease Omi, Serine Protease, HtrA2 Protease, Omi Serine Serine Protease HTRA2 Serine Protease Omi Serine Protease, Omi |
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| Tree number(s): |
D08.811.277.656.300.760.431 D08.811.277.656.959.350.431 D12.776.476.075.429 D12.776.575.656 D12.776.705.625 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000074923 | ||||||
| Scope note: | A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.4.21.108 | ||||||
| Public MeSH Note: | 2018; HIGH-TEMPERATURE REQUIREMENT A SERINE PEPTIDASE 2 was indexed under SERINE ENDOPEPTIDASES and MITOCHONDRIAL PROTEINS 2000-2017 |
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| History Note: | 2018 (2000) |
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| Related: |
PDZ Domains
MeSH | ||||||
| DeCS ID: | 57008 | ||||||
| Unique ID: | D000074923 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/04/05 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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High-Temperature Requirement A Serine Peptidase 2
- Preferred
| Concept UI |
M000628721 |
| Scope note | A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE. |
| Preferred term | High-Temperature Requirement A Serine Peptidase 2 |
| Entry term(s) |
HTRA2, Serine Protease High Temperature Requirement A Serine Peptidase 2 HtrA Serine Peptidase 2 HtrA2 Protease Omi Serine Protease Omi, Serine Protease Protease HTRA2, Serine Protease Omi, Serine Protease, HtrA2 Protease, Omi Serine Serine Protease HTRA2 Serine Protease Omi Serine Protease, Omi |
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