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Descriptor English: Survivin
Descriptor Spanish: Survivin
Descriptor survivina
Entry term(s) proteína 5 que contiene repeticiones IAP de baculovirus
proteína BIRC5
Scope note: Proteína inhibidora de la apoptosis que contiene un único dominio de repetición de IAP de baculovirus (BIR). Se asocia a los MICROTÚBULOS y regula la proliferación celular como componente del complejo de proteínas pasajeras de los cromosomas (CPC), realizando funciones esenciales para la localización del complejo, la alineación cromosómica, la segregación durante la MITOSIS y la CITOQUINESIS y el ensamblaje del HUSO MITÓTICO. Se expresa en células renales y hepáticas fetales y presenta una expresión alta en el ADENOCARCINOMA y en el LINFOMA de alto grado.
Descriptor Portuguese: Survivina
Descriptor French: Survivine
Entry term(s): BIRC5 Protein
Baculoviral IAP Repeat containing Protein 5
Baculoviral IAP Repeat-containing Protein 5
Tree number(s): D12.644.360.075.437.625
D12.776.167.576
D12.776.220.600.450.495
D12.776.476.075.437.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077022
Scope note: An apoptosis inhibitory protein that contains a single baculoviral IAP repeat (BIR) domain. It associates with MICROTUBULES and functions to regulate cell proliferation as a component of the chromosome passage protein complex (CPC), performing essential roles for localization of the complex, chromosome alignment, segregation during MITOSIS and CYTOKINESIS, and assembly of the MITOTIC SPINDLE. It is expressed by fetal kidney and liver cells and highly expressed in ADENOCARCINOMA and high-grade LYMPHOMA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Inhibitor of Apoptosis Proteins (2012-2018)
Microtubule-Associated Proteins (1997-2018)
Neoplasm Proteins (1997-2018)
Public MeSH Note: 2019
History Note: 2019
DeCS ID: 57504
Unique ID: D000077022
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/01/16
Survivin - Preferred
Concept UI M000639155
Scope note An apoptosis inhibitory protein that contains a single baculoviral IAP repeat (BIR) domain. It associates with MICROTUBULES and functions to regulate cell proliferation as a component of the chromosome passage protein complex (CPC), performing essential roles for localization of the complex, chromosome alignment, segregation during MITOSIS and CYTOKINESIS, and assembly of the MITOTIC SPINDLE. It is expressed by fetal kidney and liver cells and highly expressed in ADENOCARCINOMA and high-grade LYMPHOMA.
Preferred term Survivin
Entry term(s) BIRC5 Protein
Baculoviral IAP Repeat containing Protein 5
Baculoviral IAP Repeat-containing Protein 5



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