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Descriptor English: Survivin
Descriptor Spanish: Survivin
Descriptor survivina
Entry term(s) proteína 5 que contiene repeticiones IAP de baculovirus
proteína BIRC5
Scope note: Proteína inhibidora de la apoptosis que contiene un único dominio de repetición de IAP de baculovirus (BIR). Se asocia a los MICROTÚBULOS y regula la proliferación celular como componente del complejo de proteínas pasajeras de los cromosomas (CPC), realizando funciones esenciales para la localización del complejo, la alineación cromosómica, la segregación durante la MITOSIS y la CITOQUINESIS y el ensamblaje del HUSO MITÓTICO. Se expresa en células renales y hepáticas fetales y presenta una expresión alta en el ADENOCARCINOMA y en el LINFOMA de alto grado.
Descriptor Portuguese: Survivina
Descriptor French: Survivine
Entry term(s): Protéine BIRC5
Protéine-5 contenant des répétitions IAP baculovirales
Tree number(s): D12.644.360.075.437.625
D12.776.167.576
D12.776.220.600.450.495
D12.776.476.075.437.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077022
Scope note: An apoptosis inhibitory protein that contains a single baculoviral IAP repeat (BIR) domain. It associates with MICROTUBULES and functions to regulate cell proliferation as a component of the chromosome passage protein complex (CPC), performing essential roles for localization of the complex, chromosome alignment, segregation during MITOSIS and CYTOKINESIS, and assembly of the MITOTIC SPINDLE. It is expressed by fetal kidney and liver cells and highly expressed in ADENOCARCINOMA and high-grade LYMPHOMA.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
DeCS ID: 57504
Unique ID: D000077022
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/01/16
Survivine - Preferred
Concept UI M000639155
Preferred term Survivine
Entry term(s) Protéine BIRC5
Protéine-5 contenant des répétitions IAP baculovirales



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