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Descriptor English: Maraviroc
Descriptor Spanish: Maraviroc
Descriptor maraviroc
Entry term(s) 4,4-difluoro-N-((1S)-3-(exo-3-(3-isopropil-5-metil-4H-1,2,4-triazol-4-il)-8-azabiciclo(3.2.1)oct-8-il)-1-fenilpropil)ciclohexanocarboxamida
UK 427,857
UK 427857
UK-427,857
UK-427857
UK427,857
UK427857
celsentri
selzentry
Scope note: Derivado de ciclohexano y triazol que actúa como antagonista de los RECEPTORES CCR5. Previene la infección por cepas del VIH-1 que usan el CCR5 como correceptor para la fusión de membranas y la entrada en la célula.
Descriptor Portuguese: Maraviroc
Descriptor French: Maraviroc
Entry term(s): 4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide
Selzentry
UK 427,857
UK 427857
UK-427,857
UK-427857
UK427,857
UK427857
Tree number(s): D02.455.426.392.368.367.726
D03.383.129.799.682
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077592
Scope note: A cyclohexane and triazole derivative that acts as an antagonist of the CCR5 RECEPTOR. It prevents infection by HIV-1 virus strains which use CCR5 as a co-receptor for membrane fusion and cellular entry.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: HIV Fusion Inhibitors
CCR5 Receptor Antagonists
Registry Number: MD6P741W8A
CAS Type 1 Name: Cyclohexanecarboxamide, 4,4-difluoro-N-((1S)-3-((3-exo)-3-(3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)-
Public MeSH Note: 2019; MARAVIROC was indexed under CYCLOHEXANES and TRIAZOLES 2005-2018
History Note: 2019 (2005)
DeCS ID: 57699
Unique ID: D000077592
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/09
Maraviroc - Preferred
Concept UI M0493371
Scope note A cyclohexane and triazole derivative that acts as an antagonist of the CCR5 RECEPTOR. It prevents infection by HIV-1 virus strains which use CCR5 as a co-receptor for membrane fusion and cellular entry.
Preferred term Maraviroc
Entry term(s) 4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide
Selzentry - Narrower
Concept UI M0515080
Preferred term Selzentry
UK-427,857 - Narrower
Concept UI M0487487
Preferred term UK-427,857
Entry term(s) UK 427,857
UK 427857
UK-427857
UK427,857
UK427857



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