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Descriptor English: Amifampridine
Descriptor Spanish: Amifampridina
Descriptor amifampridina
Entry term(s) 3,4 diaminopiridina
3,4-diaminopiridina
Firdapse
Ruzurgi
fosfato de amifampridina
Scope note: Derivado de la 4-aminopiridina que actúa como bloqueador de los CANALES DEL POTASIO para aumentar la liberación de ACETILCOLINA por las terminaciones nerviosas. Se usa en el tratamiento de los SÍNDROMES MIASTÉNICOS CONGÉNITOS.
Descriptor Portuguese: Amifampridina
Descriptor French: Amifampridine
Entry term(s): 3,4 Diaminopyridine
3,4-Diaminopyridine
Amifampridine Phosphate
Firdapse
Ruzurgi
Tree number(s): D02.092.080.060.500
D03.383.725.050.060.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077770
Scope note: 4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Neuromuscular Agents
Potassium Channel Blockers
Registry Number: RU4S6E2G0J
CAS Type 1 Name: 3,4-Pyridinediamine
Public MeSH Note: 2019; see 3,4-DIAMINOPYRIDINE 1978-2018; AMIFAMPRIDINE was indexed under 4-AMINOPYRIDINE/analogs & derivatives 1990-2018; under AMINOPYRIDINES 1978-1989; and under PYRIDINES 1978-1979
History Note: 2019 (1978)
DeCS ID: 57749
Unique ID: D000077770
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2019/07/05
Amifampridine - Preferred
Concept UI M0066295
Scope note 4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.
Preferred term Amifampridine
Entry term(s) 3,4 Diaminopyridine
3,4-Diaminopyridine
Firdapse - Narrower
Concept UI M000621460
Preferred term Firdapse
Amifampridine Phosphate - Narrower
Concept UI M000621461
Preferred term Amifampridine Phosphate
Ruzurgi - Narrower
Concept UI M000649445
Preferred term Ruzurgi



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