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| Descriptor English: | Duocarmycins | ||||||
| Descriptor Spanish: |
Duocarmicinas
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| Descriptor Portuguese: | Duocarmicinas | ||||||
| Descriptor French: | Duocarmycines | ||||||
| Entry term(s): |
Duocarmycin |
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| Tree number(s): |
D03.383.129.578.275 D03.633.100.473.278 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000080890 | ||||||
| Scope note: | A group of pyrroloindole compounds often with additional spirocyclic unit(s) and their analogs originally isolated from STREPTOMYCES. They bind DNA minor grooves with adenine-N3 alkylation activity. |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Pharm Action: |
Antibiotics, Antineoplastic Antineoplastic Agents, Alkylating |
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| Previous Indexing: |
Indoles (1988-2019) Pyrroles (1988-2019) |
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| Public MeSH Note: | 2020 |
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| History Note: | 2020 |
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| DeCS ID: | 59086 | ||||||
| Unique ID: | D000080890 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2020/01/01 | ||||||
| Date of Entry: | 2019/07/08 | ||||||
| Revision Date: | 2019/05/17 |
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CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds -
CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds
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Duocarmycins
- Preferred
| Concept UI |
M000648583 |
| Scope note | A group of pyrroloindole compounds often with additional spirocyclic unit(s) and their analogs originally isolated from STREPTOMYCES. They bind DNA minor grooves with adenine-N3 alkylation activity. |
| Preferred term | Duocarmycins |
| Entry term(s) |
Duocarmycin |
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