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Descriptor English: Genes, Lethal
Descriptor Spanish: Genes Letales
Descriptor genes letales
Scope note: Genes cuya pérdida o ganancia de función por MUTACIÓN se sigue de la muerte del portador antes de la madurez. Pueden ser genes esenciales (GENES ESENCIALES) necesarios para la viabilidad o genes que producen bloqueo funcional de la función de un gen esencial siendo la función de ese gen esencial necesaria para la viabilidad.
Descriptor Portuguese: Genes Letais
Descriptor French: Gènes létaux
Entry term(s): Allele, Lethal
Alleles, Lethal
Gene, Lethal
Lethal Allele
Lethal Alleles
Lethal Gene
Lethal Genes
Tree number(s): G05.360.340.024.340.350
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005804
Scope note: Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Genes (1966-1967)
Public MeSH Note: 68
History Note: 68
Related: Synthetic Lethal Mutations MeSH
DeCS ID: 5942
Unique ID: D005804
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1968/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/30
Genes, Lethal - Preferred
Concept UI M0009099
Scope note Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.
Preferred term Genes, Lethal
Entry term(s) Gene, Lethal
Lethal Gene
Lethal Genes
Alleles, Lethal - Narrower
Concept UI M0511448
Preferred term Alleles, Lethal
Entry term(s) Allele, Lethal
Lethal Allele
Lethal Alleles



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