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Descriptor English: Immunoglobulin Idiotypes
Descriptor Spanish: Idiotipos de Inmunoglobulinas
Descriptor idiotipos de inmunoglobulinas
Entry term(s) idiotipos de Ig
Scope note: Determinantes singulares controlados genéticamente presentes en los ANTICUERPOS cuya especificidad está limitada a un único grupo de proteínas (p. ej., otra molécula de anticuerpo o una proteína individual de mieloma). Parece que el idiotipo representa la antigenicidad del sitio de unión al antígeno del anticuerpo y que está codeterminado genéticamente con él. Se han localizado de modo preciso los determinantes idiotípicos en la REGIÓN VARIABLE DE LAS INMUNOGLOBULINAS de ambas cadenas polipeptídicas de las inmunoglobulinas.
Descriptor Portuguese: Idiótipos de Imunoglobulinas
Descriptor French: Idiotypes des immunoglobulines
Entry term(s): Idiotype, Ig
Idiotype, Immunoglobulin
Idiotypes, Ig
Idiotypes, Immunoglobulin
Ig Idiotype
Ig Idiotypes
Immunoglobulin Idiotype
Tree number(s): D12.644.541.500.745
D12.776.124.486.485.680.745
D12.776.124.790.651.680.745
D12.776.377.715.548.680.745
D23.050.550.750
G02.111.570.060.425.580
G12.500.450
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007130
Scope note: Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Anti-Antibodies (1966-1969)
Antibody Specificity (1970-1978)
Antigenic Determinants (1970-1978)
Binding Sites, Antibody (1973-1978)
Public MeSH Note: 79
History Note: 79
Entry Version: IG IDIOTYPES
DeCS ID: 7313
Unique ID: D007130
NLM Classification: QW 601
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1979/01/01
Date of Entry: 1978/01/27
Revision Date: 2019/07/05
Immunoglobulin Idiotypes - Preferred
Concept UI M0011109
Scope note Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.
Preferred term Immunoglobulin Idiotypes
Entry term(s) Idiotype, Ig
Idiotype, Immunoglobulin
Idiotypes, Ig
Idiotypes, Immunoglobulin
Ig Idiotype
Ig Idiotypes
Immunoglobulin Idiotype



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