DeCS

Descriptor English:

Mechlorethamine

Descriptor Spanish:

Mecloretamina

Spanish from Spain

Descriptor	mecloretamina
Entry term(s)	N-óxido de mostaza nitrogenada cloretacina clormetina mostaza nitrogenada mustina óxido de mecloretamina
Scope note:	Agente biológico alquilante con efectos citotóxicos debidos a la formación de ADUCTOS DE ADN y enlaces intercatenarios de ADN, por lo que inhibe las células que proliferan rápidamente. El clorhidrato es un antineoplásico que se utiliza en el tratamiento de la ENFERMEDAD DE HODGKIN y el LINFOMA.

Descriptor Portuguese:

Mecloretamina

Descriptor French:

Chlorméthine

Entry term(s):

Chlorhydrate de chlorméthine
NSC-10107
NSC-762
NSC10107
NSC762
Oxyde de chlorméthine

Tree number(s):

D02.455.526.728.650.529

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D008466

Scope note:

A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Alkylating Agents
Chemical Warfare Agents
Irritants
Antineoplastic Agents, Alkylating

Registry Number:

50D9XSG0VR

CAS Type 1 Name:

Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-

DeCS ID:

8635

Unique ID:

D008466

NLM Classification:

QV 269