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Descriptor English: Melphalan
Descriptor Spanish: Melfalán
Descriptor melfalán
Entry term(s) medfalán
merfalán
mostaza de fenilalanina
sarcolisina
Scope note: Mostaza nitrogenada alquilante que se utiliza como antineoplásico en la forma de levo isómero - MELFALÁN, la mezcla racémica - MERFALÁN, y el dextro isómero - MEDFALÁN; tóxico sobre la médula ósea, pero escasa acción vesicante; carcinógeno potencial.
Descriptor Portuguese: Melfalan
Descriptor French: Melphalan
Entry term(s): 4-(Bis(2-chloroethyl)amino)phenylalanine
Alkeran
L-PAM
Medphalan
Merphalan
Mustard, Phenylalanine
Phenylalanine Mustard
Sarcolysine
Sarkolysin
Tree number(s): D02.455.526.728.650.594
D12.125.072.050.685.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008558
Scope note: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents, Alkylating
Myeloablative Agonists
Registry Number: Q41OR9510P
CAS Type 1 Name: L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-
Public MeSH Note: PEPTICHEMIO was see under NITROGEN MUSTARD COMPOUNDS 1975-80
DeCS ID: 8727
Unique ID: D008558
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Melphalan - Preferred
Concept UI M0013330
Scope note An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Preferred term Melphalan
Entry term(s) 4-(Bis(2-chloroethyl)amino)phenylalanine
L-PAM
Mustard, Phenylalanine
Phenylalanine Mustard
Medphalan - Related but not broader or narrower
Concept UI M0013329
Preferred term Medphalan
Sarkolysin - Related but not broader or narrower
Concept UI M0013331
Preferred term Sarkolysin
Entry term(s) Merphalan
Sarcolysine
Alkeran - Narrower
Concept UI M0013332
Preferred term Alkeran



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