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Descriptor English: Melphalan
Descriptor Spanish: Melfalán
Descriptor melfalán
Entry term(s) medfalán
merfalán
mostaza de fenilalanina
sarcolisina
Scope note: Mostaza nitrogenada alquilante que se utiliza como antineoplásico en la forma de levo isómero - MELFALÁN, la mezcla racémica - MERFALÁN, y el dextro isómero - MEDFALÁN; tóxico sobre la médula ósea, pero escasa acción vesicante; carcinógeno potencial.
Descriptor Portuguese: Melfalan
Descriptor French: Melphalan
Entry term(s): 4-[Bis(2-chloroéthyl)amino]-L-phénylalanine
Sarcolysine
Tree number(s): D02.455.526.728.650.594
D12.125.072.050.685.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008558
Scope note: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Antineoplastic Agents, Alkylating
Myeloablative Agonists
Registry Number: Q41OR9510P
CAS Type 1 Name: L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-
DeCS ID: 8727
Unique ID: D008558
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Melphalan - Preferred
Concept UI M0013330
Preferred term Melphalan
Entry term(s) 4-[Bis(2-chloroéthyl)amino]-L-phénylalanine
Sarcolysine - Related but not broader or narrower
Concept UI M0013331
Preferred term Sarcolysine



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