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Descriptor English: Anthramycin
Descriptor Spanish: Antramicina
Descriptor antramicina
Scope note: Antibiótico antineoplásico de ámplio espectro, aislado a partir del Streptomyces refuineus var. termoetable. Posee baja toxicidad, alguna actividad frente a tricomonas y Endamoeba, e inhibe la síntesis de ARN y ADN. Se une irreversiblemente al ADN.
Descriptor Portuguese: Antramicina
Descriptor French: Antramycine
Tree number(s): D03.633.100.079.080.070.050
D03.633.300.060
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000876
Scope note: A broad-spectrum spectrum antineoplastic antibiotic isolated from Streptomyces refuineus var. thermotolerans. It has low toxicity, some activity against Trichomonas and Endamoeba, and inhibits RNA and DNA synthesis. It binds irreversibly to DNA.
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Antibiotics, Antineoplastic
Registry Number: 0WZD9Y66WN
CAS Type 1 Name: 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))-
DeCS ID: 891
Unique ID: D000876
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/11
Revision Date: 2016/05/27
Antramycine - Preferred
Concept UI M0001309
Preferred term Antramycine



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