DeCS

Descriptor English:

Acetazolamide

Descriptor Spanish:

Acetazolamida

Spanish from Spain

Descriptor

acetazolamida

Scope note:

Uno de los INHIBIDORES DE LA ANHIDRASA CARBÓNICA que a veces es efectiva contra los episodios convulsivos de ausencia. En ocasiones también es efectiva como coadyuvante en el tratamiento de los episodios tónico-clónicos, mioclónicos y convulsiones atónicas, particularmente en mujeres cuyas convulsiones aparecen o se exacerban en momentos específicos del ciclo menstrual. Sin embargo, su utilidad es frecuentemente transitoria por la rápida aparición de tolerancia. Su acción antiepiléptica puede deberse a su efecto inhibidor sobre la anhidrasa carbónica encefálica, lo que conduce a un incremento del gradiente de cloro transneuronal, un incremento del cloro circulante, y una mayor inhibición. (Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Descriptor Portuguese:

Acetazolamida

Descriptor French:

Acétazolamide

Entry term(s):

Acétazolamide de monosodium
Acétazolamide de sodium
Acétazolamide monosodique
Acétazolamide sodique

Tree number(s):

D02.886.675.867.060
D03.383.129.708.867.060

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000086

Scope note:

One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Anticonvulsants
Carbonic Anhydrase Inhibitors
Diuretics

Registry Number:

O3FX965V0I

CAS Type 1 Name:

Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-

DeCS ID:

Unique ID:

D000086

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established: