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Descriptor English: Nucleic Acid Denaturation
Descriptor Spanish: Desnaturalización de Ácido Nucleico
Descriptor desnaturalización de ácidos nucleicos
Entry term(s) derretimiento del ADN
desnaturalización del ADN
desnaturalización del ARN
Scope note: Desorganización de la estructura secundaria de los ácidos nucleicos por el calor, pH extremo o tratamiento químico. El ADN bicatenario es "derretido" por disociación de enlaces no covalentes de hidrógeno e interacciones hidrofóbicas. El ADN desnaturalizado aparece como una estructura flexible de cadena sencilla. Los efectos de la desnaturalización sobre el ARN son similares aunque menos pronunciados y en gran medida reversibles.
Descriptor Portuguese: Desnaturação de Ácido Nucleico
Descriptor French: Dénaturation d'acide nucléique
Entry term(s): Acid Denaturation, Nucleic
DNA Denaturation
DNA Melting
Denaturation, DNA
Denaturation, Nucleic Acid
Denaturation, RNA
Nucleic Acid Denaturations
RNA Denaturation
Tree number(s): E05.393.640
G02.111.603
G05.627
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009691
Scope note: Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
Annotation: IM general only; coord NIM with DNA or RNA or specific (IM)
Allowable Qualifiers: DE drug effects
GE genetics
PD pharmacology
RE radiation effects
Public MeSH Note: 70
History Note: 70(67)
Related: RNA Stability MeSH
DeCS ID: 9878
Unique ID: D009691
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1970/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/17
Nucleic Acid Denaturation - Preferred
Concept UI M0015049
Scope note Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
Preferred term Nucleic Acid Denaturation
Entry term(s) Acid Denaturation, Nucleic
Denaturation, Nucleic Acid
Nucleic Acid Denaturations
RNA Denaturation - Narrower
Concept UI M0498355
Preferred term RNA Denaturation
Entry term(s) Denaturation, RNA
DNA Denaturation - Narrower
Concept UI M0498354
Preferred term DNA Denaturation
Entry term(s) DNA Melting
Denaturation, DNA



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