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Descriptor English: | Nucleic Acid Denaturation | ||||||
Descriptor Spanish: |
Desnaturalización de Ácido Nucleico
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Descriptor Portuguese: | Desnaturação de Ácido Nucleico | ||||||
Descriptor French: | Dénaturation d'acide nucléique | ||||||
Entry term(s): |
Dénaturation de l'ADN Dénaturation de l'ARN Fusion de l'ADN |
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Tree number(s): |
E05.393.640 G02.111.603 G05.627 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D009691 | ||||||
Scope note: | Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible. |
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Annotation: | IM general only; coord NIM with DNA or RNA or specific (IM) |
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Allowable Qualifiers: |
DE effets des médicaments et des substances chimiques GE génétique PD pharmacologie RE effets des radiations |
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Related: |
Stabilité de l'ARN
MeSH | ||||||
DeCS ID: | 9878 | ||||||
Unique ID: | D009691 | ||||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
Date Established: | 1970/01/01 | ||||||
Date of Entry: | 1999/01/01 | ||||||
Revision Date: | 2016/06/17 |
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TECHNIQUES ET ÉQUIPEMENTS ANALYTIQUES, DIAGNOSTIQUES ET THÉRAPEUTIQUES
Techniques d'investigation [E05]Techniques d'investigation -
PHÉNOMÈNES ET PROCESSUS
Phénomènes chimiques [G02]Phénomènes chimiques -
PHÉNOMÈNES ET PROCESSUS
Phénomènes génétiques [G05]Phénomènes génétiques
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Dénaturation d'acide nucléique
- Preferred
Dénaturation de l'ARN
- Narrower
Dénaturation de l'ADN
- Narrower
Concept UI |
M0015049 |
Preferred term | Dénaturation d'acide nucléique |
Concept UI |
M0498355 |
Preferred term | Dénaturation de l'ARN |
Concept UI |
M0498354 |
Preferred term | Dénaturation de l'ADN |
Entry term(s) |
Fusion de l'ADN |
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