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Descriptor English: Nucleic Acid Denaturation
Descriptor Spanish: Desnaturalización de Ácido Nucleico
Descriptor desnaturalización de ácidos nucleicos
Entry term(s) derretimiento del ADN
desnaturalización del ADN
desnaturalización del ARN
Scope note: Desorganización de la estructura secundaria de los ácidos nucleicos por el calor, pH extremo o tratamiento químico. El ADN bicatenario es "derretido" por disociación de enlaces no covalentes de hidrógeno e interacciones hidrofóbicas. El ADN desnaturalizado aparece como una estructura flexible de cadena sencilla. Los efectos de la desnaturalización sobre el ARN son similares aunque menos pronunciados y en gran medida reversibles.
Descriptor Portuguese: Desnaturação de Ácido Nucleico
Descriptor French: Dénaturation d'acide nucléique
Entry term(s): Dénaturation de l'ADN
Dénaturation de l'ARN
Fusion de l'ADN
Tree number(s): E05.393.640
G02.111.603
G05.627
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009691
Scope note: Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
Annotation: IM general only; coord NIM with DNA or RNA or specific (IM)
Allowable Qualifiers: DE effets des médicaments et des substances chimiques
GE génétique
PD pharmacologie
RE effets des radiations
Related: Stabilité de l'ARN MeSH
DeCS ID: 9878
Unique ID: D009691
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1970/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/17
Dénaturation d'acide nucléique - Preferred
Concept UI M0015049
Preferred term Dénaturation d'acide nucléique
Dénaturation de l'ARN - Narrower
Concept UI M0498355
Preferred term Dénaturation de l'ARN
Dénaturation de l'ADN - Narrower
Concept UI M0498354
Preferred term Dénaturation de l'ADN
Entry term(s) Fusion de l'ADN



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